General description of the NeoOpioid project

This project is designed as a comprehensive study aiming to investigate the clinical efficacy and safety effects of opioid therapy in newborns as well as to determine clinical practices across Europe. The NeoOpioid project will advance the science of neonatal pain and stress, the clinical practice of analgesia, the pharmacokinetic determinants, while documenting current therapies and guidelines and developing a new European standard of care for pain relief in its most vulnerable population.


The NeoOpioid project is divided into 6 Work Packages (WP), of which EUROPAIN, the present study, is WP 5.


The 6 Work Packages included in the NeoOpioid project are:


  1. Management
  2. Dose optimization (morphine and fentanyl)
  3. Safety and clinical effects (morphine and fentanyl)
  4. New child friendly formulation (morphine)
  5. European survey – EUROPAIN Survey (This is the object of this website)
  6. Administration

The coordinator of the NeoOpioid Project is

Prof. Hugo Lagercrantz
Neonatal Research. Unit Q2:07
Department of Woman and Child Health
Karolinska Institutet
Astrid Lindgren Children´s Hospital
S-171 76 Stockholm


The NeoOpioid Project has received a Grant from the 7th Framework Program

Project title: NeoOpioid—No Pain during infancy by adapting off-patent medicines
Collaborative project


The NeoOpioid Consortium

The NeoOpioid project is run by the NeoOpioid Consortium which is coordinated by Karolinska Institutet, Stockholm, Sweden. It is constituted by the following 12 partners (numbers are partner-numbers):



1. Karolinska Institutet (KI), Sweden

3. Lunds Universitet (ULUND), Sweden

4. Örebro Universitet (ORU), Sweden

5. Erasmus Universitair Medisch Centrum Rotterdamerasmus MC (EMC), Netherlands

9. EPMC Pharma SPRL (EPMCP), Belgium

10. Helsingin Ja Uudenmaan Sairaanhoitopiirin Kuntayhtyma (HUS), Finland

11 The University of Edinburgh (UEDIN), United Kingdom

12. Assistance Publique-Hôpitaux De Paris (AP-HP), France

14. Friedrich-Alexander Universitaet Erlangen-Nuremberg (FAU), Germany

15. University of Leicester (ULEIC), United Kingdom.

16. Hôpital Erasme – ULB, 1070 Bruxelles, Belgium





This project was supported by the European Community's Seventh Framework Programme under grant agreement no. 223767