Definitions used in this study

Bolus= administration in a short time (some seconds or minutes) of all the prescribed dose at once

Intermittent= administration of the medication with starting and stopping at regular intervals

Noninvasive ventilation (NIV) = administration of ventilatory support without using an invasive artificial airway (endotracheal tube or tracheostomy tube). It includes a variety of interfaces (mouth piece or nasal, face, or helmet mask). Some examples are continuous positive airway pressure [CPAP]), Bilevel positive airway pressure [BiPAP], etc


WARNING : the START of the non invasive ventilation (NIV) denotes the beginning of this mode of ventilation and the END indicates that this mode is no longer indicated. The small breaks in NIV are not accounted as new periods of NIV. If NIV is stopped for more than 24h that counts as a new NIV period..

Conventional tracheal ventilation= mechanical ventilation through a tracheal tube using pressure or volume control ventilators

High frequency ventilation= ventilation with small tidal volumes (less than anatomical dead space) and very high ventilator rates (Examples: oscillators, jet ventilation, etc)

ECMO or AREC: Extracorporeal membrane oxygenation

Spontaneous ventilation= Normal, unassisted breathing in which the neonate creates the pressure gradient through muscular movements that move air into and out of the lungs. No pressure device is used. A nasal delivery of low flow oxygen (without pressure) is included in spontaneous ventilation

PAPER COPY of the data collection form

Regulatory documents, data collection forms and the global protocol have been removed from this free access website after the end of the study.